abstract：:Hematopoietic stem cell transplantation (HSCT) for autoimmune diseases have been, because of safety reasons, overwhelmingly autologous. Results are, in general, encouraging with improvement in quality of life, a remission of up to several years, and perhaps in some diseases improved survival. This indicates that furth...

journal_title：Bone marrow transplantation

authors： Oyama Y,Traynor AE,Barr W,Burt RK

更新日期：2003-08-01 00:00:00

abstract：:Busulfan is currently used as a main component in the conditioning regimen prior to allogeneic stem cell transplantation (SCT). Several studies have shown a correlation between exposure to busulfan and transplantation-related liver toxicity, such as venoocclusive disease (VOD) in patients undergoing SCT. Busulfan is m...

journal_title：Bone marrow transplantation

authors： Sjöö F,Aschan J,Barkholt L,Hassan Z,Ringdén O,Hassan M

更新日期：2003-08-01 00:00:00

abstract：SUMMARY:Hematopoietic chimerism (HpC) was assayed monthly using a sensitive, polymerase chain reaction (PCR) -based method in consecutive patients. Between January 1998 and April 2002, 181 patients underwent non-T cell depleted allogeneic hematopoietic cell transplantation (HCT). A total of 163 patients were evaluable ...

journal_title：Bone marrow transplantation

authors： Lee KH,Lee JH,Choi SJ,Lee JH,Kim S,Seol M,Lee YS,Kim WK,Kwon MR,Choi SJ,Park CJ,Chi HS,Lee JS

更新日期：2003-08-01 00:00:00

abstract：:The purpose of this study was to evaluate if the tumor load, as determined by a real-time quantitative PCR (RQ-PCR) assay, correlated with the clinical course of follicular lymphoma patients after stem cell transplantation (SCT). Cryopreserved bone marrow and/or peripheral blood samples obtained at different time inte...

journal_title：Bone marrow transplantation

authors： Chang CC,Bredeson C,Juckett M,Logan B,Keever-Taylor CA

更新日期：2003-08-01 00:00:00

abstract：:This retrospective study compares the reconstitution of T, B and NK cells in three groups of patients transplanted for haematological malignancies with grafts from their HLA-identical sibling donors. In all, 15 patients received PBSC after a nonmyeloablative conditioning regimen consisting of fludarabine and 200 cGy T...

journal_title：Bone marrow transplantation

authors： Petersen SL,Ryder LP,Björk P,Madsen HO,Heilmann C,Jacobsen N,Sengeløv H,Vindeløv LL

更新日期：2003-07-01 00:00:00

abstract：:A total of 81 adults with acute myeloid leukemia (AML) (47% favorable karyotypes) were autografted in first remission after melphalan-total body irradiation, having received 0 (n=7), 1 (n=19), 2 (n=51), or 3 (n=4) consolidation chemotherapy cycles before harvest. The cumulative 5-year incidences of relapse and transpl...

journal_title：Bone marrow transplantation

authors： Mehta J,Powles R,Sirohi B,Treleaven J,Swansbury GJ,Kulkarni S,Saso R,Singhal S

更新日期：2003-07-01 00:00:00

abstract：:We retrospectively analyzed red blood cell (RBC) support and alloimmunization rate in 218 consecutive patients - 128 from the Pediatric Department and 90 from the adult Hematology Department - undergoing hematopoietic stem cell transplantation (HSCT) between 1994 and 2000. In the pre-HSCT period, the pediatric patient...

journal_title：Bone marrow transplantation

authors： Perseghin P,Balduzzi A,Galimberti S,Dassi M,Baldini V,Valsecchi MG,Pioltelli P,Bonanomi S,Faccini P,Rovelli A,Pogliani EM,Uderzo C

更新日期：2003-07-01 00:00:00

abstract：:Over the last 15 years, we have performed a total of 30 haematopoietic stem cell transplants on 27 children suffering from Hurler's syndrome. These children were of median age 11 months at the time of diagnosis and 25 months at the time of transplantation. The phenotype was severe in 21 cases (78%). The donor was fami...

journal_title：Bone marrow transplantation

authors： Souillet G,Guffon N,Maire I,Pujol M,Taylor P,Sevin F,Bleyzac N,Mulier C,Durin A,Kebaili K,Galambrun C,Bertrand Y,Froissart R,Dorche C,Gebuhrer L,Garin C,Berard J,Guibaud P

更新日期：2003-06-01 00:00:00

abstract：:We retrospectively analyzed the outcome of 67 patients with breast (n=24), ovarian (n=11) or testicular cancer (n=32) treated for relapse after high-dose chemotherapy (HDC) and peripheral blood stem cell (PBSC) transplantation. Treatment, survival and toxicity were analyzed. Patients with breast, ovarian or testicular...

journal_title：Bone marrow transplantation

authors： Bojko P,Akca A,Seeber S

更新日期：2003-06-01 00:00:00

abstract：:We report the successful treatment of two acute lympho- blastic leukemia (ALL) patients who relapsed following allogeneic bone marrow transplantation (allo-BMT) with allogeneic peripheral blood sem cell transplantation(allo-PBSCT) and donor lymphocyte infusion (DLI) from the same HLA-identical related donors as those ...

journal_title：Bone marrow transplantation

authors： Ishikawa J,Maeda T,Kashiwagi H,Yoshida H,Takahashi I,Kawamoto SI,Yamada M,Kato H,Nishiura T,Tomiyama Y,Matsuzawa Y

更新日期：2003-06-01 00:00:00

abstract：:We evaluated 120 leukapheresis procedures (93 patients), in order to detect clinical factors that influence the efficiency of CD34+ collection using Cobe Spectra trade mark cell separators. Hematocrit was >27% and platelet count >30 000/microl in >95% of patients. Platelet transfusions were given if the postprocedure ...

journal_title：Bone marrow transplantation

authors： Sarkodee-Adoo C,Taran I,Guo C,Buadi F,Murthy R,Cox E,Lopez R,Westphal S,Shope S,O'Connell B,Wethers L,Meisenberg B

更新日期：2003-05-01 00:00:00

abstract：:Hemorrhagic cystitis (HC) is a common and sometimes life-threatening complication of hemopoietic cell transplantation (HCT) occurring in 7-52% of transplant recipients. In this setting it is usually either related to the use of cyclophosphamide or to a viral infection (BK, JC viruses and adenovirus type 11). Treatment...

journal_title：Bone marrow transplantation

authors： Giné E,Rovira M,Real I,Burrel M,Montaña J,Carreras E,Montserrat E

更新日期：2003-05-01 00:00:00

abstract：:We performed a randomized study to compare 'G-CSF alone' (administered at dose of 10 mcg/kg/day) and 'cyclophosphamide plus G-CSF' (cyclophosphamide at dose of 4 g/m(2) and G-CSF at dose of 10 microg/kg/day), as PBPC mobilization schedules in 52 patients with NHL or HD. Randomization was stratified according to the am...

journal_title：Bone marrow transplantation

authors： Milone G,Leotta S,Indelicato F,Mercurio S,Moschetti G,Di Raimondo F,Tornello A,Consoli U,Guido G,Giustolisi R

更新日期：2003-05-01 00:00:00

abstract：:To establish the incidence of CMV viremia after allogeneic blood stem cell transplantation, we studied 51 consecutive allogeneic peripheral blood stem cell (PBSC) transplant recipients. A total of 12 recipients were at moderate risk for CMV disease and 39 were at high risk. Conditioning regimens varied, but GvHD proph...

journal_title：Bone marrow transplantation

authors： Verma A,Devine S,Morrow M,Chen YH,Mihalov M,Peace D,Stock W,Pursell K,Wickrema A,Yassine M,Jessop E,van Besien K

更新日期：2003-05-01 00:00:00

abstract：:The indolent non-Hodgkin's lymphomas are theoretically curable through allogeneic haematopoietic stem cell transplantation (allo-HSCT). The applicability of standard conditioning allo-HSCT is, however, restricted by its toxicity. Recently, reduced-intensity conditioning regimens have demonstrated efficacy with signifi...

journal_title：Bone marrow transplantation

authors： Ho AY,Devereux S,Mufti GJ,Pagliuca A

更新日期：2003-04-01 00:00:00

abstract：:We report the response to the ABL kinase inhibitor imatinib mesylate (STI571) in a patient with chronic myeloid leukemia (CML) who relapsed twice after dose-reduced allogeneic stem cell transplantation (alloSCT) for B lymphoid blast crisis (BC) and failed to develop an antileukemic response despite grade 3 graft-versu...

journal_title：Bone marrow transplantation

authors： Wassmann B,Scheuring U,Thiede C,Pfeifer H,Bornhäuser M,Griesinger F,Hochhaus A,Schleyer E,Gschaidmeier H,Hoelzer D,Ottmann OG

更新日期：2003-04-01 00:00:00

abstract：:High-dose melphalan (HDM) has been adopted as standard therapy in the treatment of multiple myeloma. This treatment is associated with non-selective cytotoxicity, causing oral mucositis as the major non-hematological side-effect. Amifostine is a cytoprotector which prevents toxicity induced by anticancer therapy. We p...

journal_title：Bone marrow transplantation

authors： Thieblemont C,Dumontet C,Saad H,Roch N,Bouafia F,Arnaud P,Hequet O,Espinouse D,Salles G,Roy P,Eljaafari-Corbin A,Du Manoir-Baumgarten C,Coiffier B

更新日期：2002-12-01 00:00:00

abstract：:From August 1995 to December 1997, 15 patients with stage III-IV ovarian cancer were treated with outpatient intensive chemotherapy with G-CSF and stem cell support. The first cycle consisted of cyclophophamide IV 6 g/m(2); second, third, fourth and fifth paclitaxel 250 mg/m(2) and the sixth and seventh carboplatin AU...

journal_title：Bone marrow transplantation

authors： Viret F,Bertucci F,Genre D,Gravis G,Chabannon C,Conte M,Houvenaeghel G,Maraninchi D,Viens P

更新日期：2002-12-01 00:00:00

abstract：:We conducted a controlled, double-blind study of parenteral glutamine supplementation in an unselected group of consecutive autologous transplant patients. Patients received 30 g of alanyl-glutamine dipeptide (Dipeptiven; Fresenius-Kabi, Bad Homburg, Germany) or glutamine-free amino acid solution i.v. from day +1 to d...

journal_title：Bone marrow transplantation

authors： Pytlík R,Benes P,Patorková M,Chocenská E,Gregora E,Procházka B,Kozák T

更新日期：2002-12-01 00:00:00

abstract：:Management of iatrogenic gonadal reproductive failure and sexual morbidity assumes a priority, especially in young recipients of high-dose chemotherapy and stem cell transplantation (SCT). Hormone replacement treatment (HRT) is beneficial for correction of sexual symptoms and osteoporosis in both sexes, especially in ...

journal_title：Bone marrow transplantation

authors： Chatterjee R,Kottaridis PD

更新日期：2002-11-01 00:00:00

abstract：:In an attempt to improve the dismal prognosis of adults with recurrent medulloblastoma, six patients were treated with aggressive salvage therapy including high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT). At relapse, all patients underwent surgical debulking followed by HDCT/ASCT and then...

journal_title：Bone marrow transplantation

authors： Zia MI,Forsyth P,Chaudhry A,Russell J,Stewart DA

更新日期：2002-11-01 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) is a multiorgan disorder with skin manifestations resembling scleroderma. Since photopheresis, a treatment that induces an anticlonotypic immune response, has proven to be effective in both cutaneous T cell lymphomas with circulating clonal T cells and in cGVHD, we have search...

journal_title：Bone marrow transplantation

authors： French LE,Alcindor T,Shapiro M,McGinnis KS,Margolis DJ,Porter D,Leonard DG,Rook AH,Foss F

更新日期：2002-10-01 00:00:00

abstract：:A 20-month-old boy with infantile leukemia was treated with total body irradiation, etoposide, cyclophosphamide and unrelated cord blood transplantation with a one-antigen mismatch. He relapsed on day 100 and achieved remission after ubenimex administration, and also developed chronic graft-versus-host disease of the ...

journal_title：Bone marrow transplantation

authors： Okada H,Nomi K,Hamatani S,Kuromi T,Nanba M,Imai T,Isobe K,Itoh S

更新日期：2002-10-01 00:00:00

abstract：:The administration of G-CSF post transplant has been shown to accelerate the time to neutrophil engraftment. However, this does not necessarily translate into a meaningful clinical benefit to the patient. This randomized study was designed to determine the role of G-CSF following transplantation in patients with breas...

journal_title：Bone marrow transplantation

authors： Hornedo J,Solá C,Solano C,López JJ,Alonso S,Lluch A,Ojeda B,Garcia-Conde J,Cortés-Funes H,SOLTI Group.

更新日期：2002-05-01 00:00:00

abstract：:The present study analyses the influence of high-dose chemotherapy (HD) and autologous stem cell transplantation on natural and vaccine-induced specific immunity in breast cancer patients. Peripheral blood was collected from five breast cancer patients at serial time points in connection with treatment and in a follow...

journal_title：Bone marrow transplantation

authors： Svane IM,Nikolajsen K,Hansen SW,Kamby C,Nielsen DL,Johnsen HE

更新日期：2002-04-01 00:00:00

abstract：:Unusual cytomegalovirus (CMV)-related complications were seen after autologous stem cell transplantation (SCT) in a 50-year-old patient with diffuse large B cell lymphoma. One month after SCT, the patient developed life-threatening upper gastrointestinal tract (GIT) bleeding with several episodes of hemorrhagic shock....

journal_title：Bone marrow transplantation

authors： Cohen Y,Paltiel O,Amir G,Da'as N,Engelhard D,Polliack A

更新日期：2002-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) antigenemia and quantitative real-time polymerase chain reaction (PCR) were compared for monitoring of CMV reactivation after allogeneic stem cell transplantation. The number of CMV antigen-positive cells by the antigenemia assay and the level of CMV DNA by real-time PCR correlated well. The sens...

journal_title：Bone marrow transplantation

authors： Yakushiji K,Gondo H,Kamezaki K,Shigematsu K,Hayashi S,Kuroiwa M,Taniguchi S,Ohno Y,Takase K,Numata A,Aoki K,Kato K,Nagafuji K,Shimoda K,Okamura T,Kinukawa N,Kasuga N,Sata M,Harada M

更新日期：2002-04-01 00:00:00

abstract：:Acquired factor VII (FVII) deficiency in the absence of vitamin K deficiency, oral anticoagulant therapy, synthetic liver dysfunction, or DIC is rare, with only a handful of cases thus far reported. In the period from 1990 to 1996 we identified eight patients with acquired FVII deficiency, all of whom presented with p...

journal_title：Bone marrow transplantation

authors： Toor AA,Slungaard A,Hedner U,Weisdorf DJ,Key NS

更新日期：2002-03-01 00:00:00

abstract：:One hundred and ninety-three patients with hematological malignancies and a follow-up > or =1 year, treated with stem cell transplantation (45 autologous, 99 allogeneic T cell-depleted matched, 49 allogeneic T cell-depleted mismatched) from July 1985 to May 1998, were considered evaluable for the development of catara...

journal_title：Bone marrow transplantation

authors： Aristei C,Alessandro M,Santucci A,Aversa F,Tabillo A,Carotti A,Latini RA,Cagini C,Latini P

更新日期：2002-03-01 00:00:00

abstract：:A second meeting on reduced intensity allogeneic stem cell transplants (RI-HSCT) was convened in Zurich in February 2001 and focused on transplant-related mortality (TRM) and graft-versus-host disease (GVHD). Retrospective and prospective studies from the EBMT, national groups and single institutions included over 900...

journal_title：Bone marrow transplantation

authors： Bacigalupo A

更新日期：2002-02-01 00:00:00

abstract：:HSV can cause oral lesions that exacerbate chemotherapy-related mucositis. Intravenous acyclovir is effective in preventing HSV reactivations, but expensive. Valacyclovir has good bioavailability and has not been studied for prophylaxis of HSV among PCT patients. We compared the efficacy and costs of valacyclovir in p...

journal_title：Bone marrow transplantation

authors： Dignani MC,Mykietiuk A,Michelet M,Intile D,Mammana L,Desmery P,Milone G,Pavlovsky S

更新日期：2002-02-01 00:00:00

abstract：:Patients who develop veno-occlusive disease (VOD) of the liver may have low plasma levels of the natural anticoagulants protein C and antithrombin III, but large vessel thromboses are not commonly reported in these patients. We reviewed the records of 1847 consecutive patients for evidence of portal vein thrombosis. E...

journal_title：Bone marrow transplantation

authors： Kikuchi K,Rudolph R,Murakami C,Kowdley K,McDonald GB

更新日期：2002-02-01 00:00:00

abstract：:EBV viral load (EBV-VL) in PBMC was prospectively determined by semi-quantitative PCR in 85 stem cell transplants (40 genoidentical, 45 non-genoidentical) in order to characterize the kinetics of EBV-VL and to assess the ability of this measure to predict the development of EBV-induced lymphoproliferative disease (EBV...

journal_title：Bone marrow transplantation

authors： Sirvent-Von Bueltzingsloewen A,Morand P,Buisson M,Souillet G,Chambost H,Bosson JL,Bordigoni P

更新日期：2002-01-01 00:00:00

abstract：:Autologous hematopoietic stem cell transplantation (HSCT) is currently being evaluated as a therapy for patients with progressive multiple sclerosis (MS) at risk of debilitating neurological impairment. While preliminary results from a few studies have been reported, little is known about toxicities or outcome of HSCT...

journal_title：Bone marrow transplantation

authors： Oyama Y,Cohen B,Traynor A,Brush M,Rodriguez J,Burt RK

更新日期：2002-01-01 00:00:00

abstract：:Activation of donor T cells is required for the development of graft-versus-host disease (GVHD), a major complication of bone marrow transplantation. We investigated a murine model of GVHD across major and minor histocompatibility barriers. BALB/c recipients were lethally irradiated and transplanted with 10(7) bone ma...

journal_title：Bone marrow transplantation

authors： van Leeuwen L,Guiffre A,Atkinson K,Rainer SP,Sewell WA

更新日期：2002-01-01 00:00:00

abstract：:Expression of the chemokine receptor CXCR4 on human haemopoietic stem cells (HSC) may play a crucial role in localising these cells to the bone marrow. To evaluate whether CXCR4 expression is clinically relevant we have enumerated CXCR4-positive HSC used for allogeneic transplantation and sought any relationship with ...

journal_title：Bone marrow transplantation

authors： Spencer A,Jackson J,Baulch-Brown C

更新日期：2001-12-01 00:00:00

abstract：:A 51-year-old patient with refractory CLL elected to participate in a trial of nonmyeloablative trans- plantation from an HLA-matched unrelated donor. He received low-dose fludarabine/TBI, with infusion of donor PBPC and cyclosporin (CsA)/MMF. Early post transplant he experienced explosive tumor growth with respirator...

journal_title：Bone marrow transplantation

authors： Nieto Y,Bearman SI,Shpall EJ,Jones RB,Cagnoni PJ,Rabinovitch RA,McSweeney PA

更新日期：2001-12-01 00:00:00

abstract：:We prospectively studied absolute lymphocyte (ALC) and monocyte counts (AMC), lymphocyte subsets and proliferative in vitro responses to mitogen and antigen in 12 patients with AL-amyloidosis (AL) undergoing autologous blood stem cell transplantation (SCT) with high-dose i.v. melphalan. Myeloid and lymphoid recovery (...

journal_title：Bone marrow transplantation

authors： Akpek G,Lenz G,Lee SM,Sanchorawala V,Wright DG,Colarusso T,Waraska K,Lerner A,Vosburgh E,Skinner M,Comenzo RL

更新日期：2001-12-01 00:00:00

abstract：:We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo 14 months after allo-BMT. Our results indicate that LGL can mediate in ...

journal_title：Bone marrow transplantation

authors： Mohty M,Faucher C,Gaugler B,Vey N,Sainty D,Arnoulet C,Mozziconacci MJ,Isnardon D,Gastaut JA,Maraninchi D,Olive D,Blaise D

更新日期：2001-12-01 00:00:00

abstract：:Allogeneic BMT is potentially curative for patients with acute myelogenous leukemia (AML) in first remission. However, many patients relapse after transplantation. Various immunotherapeutic options have been attempted with variable success in preventing relapse. Early identification of patients at high risk for relaps...

journal_title：Bone marrow transplantation

authors： Kumar S,Chen MG,Gastineau DA,Gertz MA,Inwards DJ,Lacy MQ,Tefferi A,Litzow MR

更新日期：2001-11-01 00:00:00